NCMP-07. CASE SERIES OF REGULARLY SCHEDULED MANNITOL INFUSIONS SHOWING WITH PROLONGED CLINICAL BENEFIT FOR MANAGEMENT OF CEREBRAL EDEMA IN GLIOMAS

Abstract Gliomas account for the vast majority of malignant primary tumors arising in central nervous system. Elevated intracranial pressure (ICP) may be a potentially devastating complication brain and hydrocephalus. Brain occupy significant space causing displacement compression delicate structures within finite compartment. The compliance relationship is nonlinear decreases as combined volume contents increases. When these compensatory mechanisms have been exhausted, increases develop with relatively small volume. diagnosis elevated ICP generally based on clinical findings corroborated by imaging studies patient's medical history. best therapy hypertension (ICH) resolution proximate cause such evacuation blood clot, resection tumor, or cerebrospinal fluid (CSF) diversion setting If modalities exhausted unavailable, osmotic diuretics mannitol can utilized. This medication reduces drawing free water out tissue into circulation, where it excreted kidneys, thus dehydrating parenchyma. common belief that effects are usually present minutes, peak at approximately one hour, last 4 to 24 hours. We report series 33 patients treated minimum 1 month regularly scheduled maintenance infusions Mannitol 1g/kg every two weeks, 64% showed improved outcomes stabilization edema symptoms. Patients expressed improvements headaches, dizziness, cognitive ability. supports bi-weekly use glioma symptomatic cerebral edema. A controlled trial should supported. also suggest mechanism action more durable response than diuresis.